Suitability of Methods to Determine Resistance to Biocidal Active Substances and Disinfectants—A Systematic Review

Biocide resistance is an increasing concern. However, it currently unknown if elevated MIC value for isolate correlates with a lower log10 reduction in suspension tests or carrier tests. The aim of this review was therefore to evaluate isolates suspected tolerance biocidal active substance reveal and impaired efficacy A Medline search done on 6 July 2022 using the following terms: “resistance suspension” (16 hits), carrier” (22 (41 “tolerance (1 hit), (4 hits) (3 hits). Studies were included when disinfectant at least two three endpoints evaluated parallel comparison control isolates. In out five studies, values did not correlate bactericidal against biocide-tolerant activity described that correlated (peracetic acid-tolerant K. pneumoniae glutaraldehyde-tolerant M. chelonae; other studies allow comparison. Overall, results from under practical conditions allowed determine clinically relevant resistance.